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Between a rock and a hard place.

Developing small-molecule inhibitors against protein-protein interaction targets is among the most difficult challenges in contemporary drug discovery. Recent developments in our understanding of this problem, and in the knowledge and tools available to address it, give cause for renewed hope, but substantial challenges remain.

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A rock and a hard place.

A solution to get the problem off, have you found it? Really? What kind of solution do you resolve the problem? From what sources? Well, there are so many questions that we utter every day. No matter how you will get the solution, it will mean better. You can take the reference from some books. And the a rock and a hard place is one book that we really recommend you to read, to get more solutio...

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Between a rock and a hard place: disclosing medical errors.

BACKGROUND Healthcare-related errors cause patient morbidity and mortality. Despite fear of reprimand, laboratory personnel have a professional obligation to rapidly report major medical errors when they are identified. Well-defined protocols regarding how and when to disclose a suspected error by a colleague do not exist. PATIENT We describe a woman with a well documented allergy to sulfamet...

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Brain stones revisited—between a rock and a hard place

OBJECTIVES AND METHODS Large intracranial calcifications are occasionally encountered in routine computed tomography (CT) scans of the brain. These calcifications, also known as "brain stones", can be classified according to location and aetiology. Combining imaging findings with relevant clinical history and physical examination can help narrow down the differential diagnosis and may allow con...

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Gem GTPase: between a ROCK and a Hard Place

Gem GTPase is a member of a protein family that includes Rad, Rem and Rem2. Although until recently precious little was known about the function of Gem, recent studies have revealed that Gem may influence cell morphology by antagonising the actions of the Rho GTPase effector protein ROCK I.

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ژورنال

عنوان ژورنال: Volume !

سال: 2002

ISSN: 2117-4148,1950-568X

DOI: 10.4000/volume.2448